Archive for ‘Disk Disease Library’
Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series
Friday, August 17th, 2012
Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical [...]
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Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical [...]
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Recent advances in disc cell biology
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2003 Jan 15;28(2):186-93 Authors: Gruber HE, Hanley EN STUDY DESIGN: There have been many advances over the past decade in understanding and experimentally modulating biologic aspects of intervertebral disc cell function. An overview of the current state of this biologic research is presented. OBJECTIVES: To provide clinicians with a review of [...]
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Spine (Phila Pa 1976). 2003 Jan 15;28(2):186-93 Authors: Gruber HE, Hanley EN STUDY DESIGN: There have been many advances over the past decade in understanding and experimentally modulating biologic aspects of intervertebral disc cell function. An overview of the current state of this biologic research is presented. OBJECTIVES: To provide clinicians with a review of [...]
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Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration
Friday, August 17th, 2012
Biomaterials. 2003 Sep;24(20):3531-41 Authors: Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T Intervertebral disc degeneration is considered to be one of the major causes of low back pain. Despite this irreversible phenomenon, attempts to decelerate disc degeneration using various techniques have been reported. However, to [...]
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Biomaterials. 2003 Sep;24(20):3531-41 Authors: Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T Intervertebral disc degeneration is considered to be one of the major causes of low back pain. Despite this irreversible phenomenon, attempts to decelerate disc degeneration using various techniques have been reported. However, to [...]
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Biologic strategies for the therapy of intervertebral disc degeneration
Friday, August 17th, 2012
Expert Opin Biol Ther. 2003 Dec;3(8):1209-14 Authors: Gruber HE, Hanley EN Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current [...]
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Expert Opin Biol Ther. 2003 Dec;3(8):1209-14 Authors: Gruber HE, Hanley EN Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current [...]
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Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
Friday, August 17th, 2012
Gene Ther. 2004 Jan;11(1):34-41 Authors: Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O’Keefe RJ, Schwarz EM Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for these conditions is available, the use of human bone marrow derived-mesenchymal stem cells (HuMSCs) has been shown [...]
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Gene Ther. 2004 Jan;11(1):34-41 Authors: Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O’Keefe RJ, Schwarz EM Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for these conditions is available, the use of human bone marrow derived-mesenchymal stem cells (HuMSCs) has been shown [...]
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Cell therapy for disc degeneration–potentials and pitfalls
Friday, August 17th, 2012
Orthop Clin North Am. 2004 Jan;35(1):85-93 Authors: Brisby H, Tao H, Ma DD, Diwan AD Disc degeneration is considered a major source of pain in patients with chronic low back pain. Novel strategies to cure or decrease the symptoms and increase the patient’s quality of life and function are under development. Until recently conservative treatment [...]
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Orthop Clin North Am. 2004 Jan;35(1):85-93 Authors: Brisby H, Tao H, Ma DD, Diwan AD Disc degeneration is considered a major source of pain in patients with chronic low back pain. Novel strategies to cure or decrease the symptoms and increase the patient’s quality of life and function are under development. Until recently conservative treatment [...]
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Stem cell regeneration of the nucleus pulposus
Friday, August 17th, 2012
Spine J. 2004 Nov-Dec;4(6 Suppl):348S-353S Authors: Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ Low back pain due to disc degeneration is one of the largest health problems faced in this nation when judged by lost work time and direct as well as indirect costs. Many experimental methods are being explored to treat or to [...]
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Spine J. 2004 Nov-Dec;4(6 Suppl):348S-353S Authors: Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ Low back pain due to disc degeneration is one of the largest health problems faced in this nation when judged by lost work time and direct as well as indirect costs. Many experimental methods are being explored to treat or to [...]
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Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans
Friday, August 17th, 2012
Clin Orthop Relat Res. 2005 Jan;(430):219-26 Authors: Zhang YG, Guo X, Xu P, Kang LL, Li J We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can survive and increase the amount of proteoglycans in intervertebral discs. We used the rabbit intervertebral disc as a model, creating three groups: an uninjected control group, [...]
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Clin Orthop Relat Res. 2005 Jan;(430):219-26 Authors: Zhang YG, Guo X, Xu P, Kang LL, Li J We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can survive and increase the amount of proteoglycans in intervertebral discs. We used the rabbit intervertebral disc as a model, creating three groups: an uninjected control group, [...]
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New strategies for disc repair: novel preclinical trials
Friday, August 17th, 2012
J Orthop Sci. 2005;10(1):112-8 Authors: Mochida J Degeneration of lumbar intervertebral discs is a major cause of low back complaints, an irreversible occurrence with no currently available treatment. Furthermore, various surgical procedures can accelerate disc degeneration. On the other hand, recent experimental studies on disc cells have demonstrated an important role for the nucleus pulposus [...]
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J Orthop Sci. 2005;10(1):112-8 Authors: Mochida J Degeneration of lumbar intervertebral discs is a major cause of low back complaints, an irreversible occurrence with no currently available treatment. Furthermore, various surgical procedures can accelerate disc degeneration. On the other hand, recent experimental studies on disc cells have demonstrated an important role for the nucleus pulposus [...]
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Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
Friday, August 17th, 2012
Biomaterials. 2006 Jan;27(3):335-45 Authors: Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, Nakai T, Ando K, Hotta T Intervertebral disc (IVD) degeneration, a common cause of low back pain in humans, is a relentlessly progressive phenomenon with no currently available effective treatment. In an attempt to solve this dilemma, we transplanted [...]
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Biomaterials. 2006 Jan;27(3):335-45 Authors: Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, Nakai T, Ando K, Hotta T Intervertebral disc (IVD) degeneration, a common cause of low back pain in humans, is a relentlessly progressive phenomenon with no currently available effective treatment. In an attempt to solve this dilemma, we transplanted [...]
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The potential role of mesenchymal stem cell therapy for intervertebral disc degeneration: a critical overview
Friday, August 17th, 2012
Neurosurg Focus. 2005 Sep 15;19(3):E4 Authors: Acosta FL, Lotz J, Ames CP Low-back pain is the most common health problem for men and women between 20 and 50 years of age, resulting in 13 million doctor visits in the US annually, with significant costs to society in terms of lost time from work and direct [...]
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Neurosurg Focus. 2005 Sep 15;19(3):E4 Authors: Acosta FL, Lotz J, Ames CP Low-back pain is the most common health problem for men and women between 20 and 50 years of age, resulting in 13 million doctor visits in the US annually, with significant costs to society in terms of lost time from work and direct [...]
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Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2005 Nov 1;30(21):2379-87 Authors: Sakai D, Mochida J, Iwashina T, Watanabe T, Nakai T, Ando K, Hotta T STUDY DESIGN: An in vivo study to assess the differentiation status of mesenchymal stem cells (MSCs) transplanted to the nucleus pulposus of degenerative discs in a rabbit model. OBJECTIVES: To evaluate the fate [...]
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Spine (Phila Pa 1976). 2005 Nov 1;30(21):2379-87 Authors: Sakai D, Mochida J, Iwashina T, Watanabe T, Nakai T, Ando K, Hotta T STUDY DESIGN: An in vivo study to assess the differentiation status of mesenchymal stem cells (MSCs) transplanted to the nucleus pulposus of degenerative discs in a rabbit model. OBJECTIVES: To evaluate the fate [...]
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Cell-based therapy for disc repair
Friday, August 17th, 2012
Spine J. 2005 Nov-Dec;5(6 Suppl):297S-303S Authors: Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ BACKGROUND CONTEXT: One of the most promising therapies for symptomatic disc degeneration involves the implantation of therapeutic cells into the degenerative disc. PURPOSE: In this article, the rationale and approaches for cell-based tissue engineering of the intervertebral disc are [...]
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Spine J. 2005 Nov-Dec;5(6 Suppl):297S-303S Authors: Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ BACKGROUND CONTEXT: One of the most promising therapies for symptomatic disc degeneration involves the implantation of therapeutic cells into the degenerative disc. PURPOSE: In this article, the rationale and approaches for cell-based tissue engineering of the intervertebral disc are [...]
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Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction
Friday, August 17th, 2012
Eur Spine J. 2006 Aug;15 Suppl 3:S406-13 Authors: Leung VY, Chan D, Cheung KM Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect [...]
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Eur Spine J. 2006 Aug;15 Suppl 3:S406-13 Authors: Leung VY, Chan D, Cheung KM Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect [...]
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Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2006 Aug 15;31(18):2036-42 Authors: Le Visage C, Kim SW, Tateno K, Sieber AN, Kostuik JP, Leong KW STUDY DESIGN: To evaluate the in vitro interactions between human mesenchymal stem cells (MSCs) and degenerative disc cells. OBJECTIVES: To demonstrate the potential of MSCs in regulating the extracellular matrix synthesis of degenerative disc [...]
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Spine (Phila Pa 1976). 2006 Aug 15;31(18):2036-42 Authors: Le Visage C, Kim SW, Tateno K, Sieber AN, Kostuik JP, Leong KW STUDY DESIGN: To evaluate the in vitro interactions between human mesenchymal stem cells (MSCs) and degenerative disc cells. OBJECTIVES: To demonstrate the potential of MSCs in regulating the extracellular matrix synthesis of degenerative disc [...]
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Biological treatment strategies for disc degeneration: potentials and shortcomings
Friday, August 17th, 2012
Eur Spine J. 2007 Apr;16(4):447-68 Authors: Paesold G, Nerlich AG, Boos N Recent advances in molecular biology, cell biology and material sciences have opened a new emerging field of techniques for the treatment of musculoskeletal disorders. These new treatment modalities aim for biological repair of the affected tissues by introducing cell-based tissue replacements, genetic modifications [...]
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Eur Spine J. 2007 Apr;16(4):447-68 Authors: Paesold G, Nerlich AG, Boos N Recent advances in molecular biology, cell biology and material sciences have opened a new emerging field of techniques for the treatment of musculoskeletal disorders. These new treatment modalities aim for biological repair of the affected tissues by introducing cell-based tissue replacements, genetic modifications [...]
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The in vivo biological effects of intradiscal recombinant human bone morphogenetic protein-2 on the injured intervertebral disc: an animal experiment
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2007 May 15;32(11):1174-80 Authors: Huang KY, Yan JJ, Hsieh CC, Chang MS, Lin RM STUDY DESIGN: Prospective analysis. OBJECTIVE: To investigate biologic influences of recombinant human bone morphogenetic protein (rhBMP)-2 on intervertebral discs after anular tears. SUMMARY OF BACKGROUND DATA: Treatments for intervertebral disc injury or degeneration are unsatisfactory. rhBMP-2, a [...]
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Spine (Phila Pa 1976). 2007 May 15;32(11):1174-80 Authors: Huang KY, Yan JJ, Hsieh CC, Chang MS, Lin RM STUDY DESIGN: Prospective analysis. OBJECTIVE: To investigate biologic influences of recombinant human bone morphogenetic protein (rhBMP)-2 on intervertebral discs after anular tears. SUMMARY OF BACKGROUND DATA: Treatments for intervertebral disc injury or degeneration are unsatisfactory. rhBMP-2, a [...]
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Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies
Friday, August 17th, 2012
Histol Histopathol. 2007 Sep;22(9):1033-41 Authors: Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA Degeneration of the intervertebral disc (IVD) is a major cause of low back pain affecting a large percentage of the population at some point in their lives. Consequently IVD degeneration and its associated low back pain has a huge socio-economic impact and [...]
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Histol Histopathol. 2007 Sep;22(9):1033-41 Authors: Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA Degeneration of the intervertebral disc (IVD) is a major cause of low back pain affecting a large percentage of the population at some point in their lives. Consequently IVD degeneration and its associated low back pain has a huge socio-economic impact and [...]
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Advances of mesenchymal stem cells transplantation for treating intervertebral disc degeneration
Friday, August 17th, 2012
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 May;21(5):502-6 Authors: Liang T, Liu H OBJECTIVE: To introduce the research of mesenchymal stem cells(MSCs) transplantation for treating intervertebral disc degeneration. METHODS: The recent original articles about the MSCs transplantation for treating intervertebral disc degeneration were extensively reviewed. RESULTS: Transplanted MSCs in intervertebral disc can [...]
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 May;21(5):502-6 Authors: Liang T, Liu H OBJECTIVE: To introduce the research of mesenchymal stem cells(MSCs) transplantation for treating intervertebral disc degeneration. METHODS: The recent original articles about the MSCs transplantation for treating intervertebral disc degeneration were extensively reviewed. RESULTS: Transplanted MSCs in intervertebral disc can [...]
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In vitro interaction between muscle-derived stem cells and nucleus pulposus cells
Friday, August 17th, 2012
Spine J. 2008 Sep-Oct;8(5):804-9 Authors: Vadalà G, Sobajima S, Lee JY, Huard J, Denaro V, Kang JD, Gilbertson LG BACKGROUND CONTEXT: Current therapies for intervertebral disc degeneration (IDD) are aimed at treating the clinical symptoms arising from IDD rather than directly treating the underlying problem. Pathophysiology of IDD is characterized by a progressive decrease in [...]
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Spine J. 2008 Sep-Oct;8(5):804-9 Authors: Vadalà G, Sobajima S, Lee JY, Huard J, Denaro V, Kang JD, Gilbertson LG BACKGROUND CONTEXT: Current therapies for intervertebral disc degeneration (IDD) are aimed at treating the clinical symptoms arising from IDD rather than directly treating the underlying problem. Pathophysiology of IDD is characterized by a progressive decrease in [...]
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Feasibility of a stem cell therapy for intervertebral disc degeneration
Friday, August 17th, 2012
Spine J. 2008 Nov-Dec;8(6):888-96 Authors: Sobajima S, Vadala G, Shimer A, Kim JS, Gilbertson LG, Kang JD BACKGROUND CONTEXT: Different strategies to supplement/replenish the disc cell population have been proposed. Recently, adult stem cells have shown promise as a cell source for a variety of tissue engineering and cell therapy applications. A stem cell can [...]
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Spine J. 2008 Nov-Dec;8(6):888-96 Authors: Sobajima S, Vadala G, Shimer A, Kim JS, Gilbertson LG, Kang JD BACKGROUND CONTEXT: Different strategies to supplement/replenish the disc cell population have been proposed. Recently, adult stem cells have shown promise as a cell source for a variety of tissue engineering and cell therapy applications. A stem cell can [...]
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Transplantation of mesenchymal stem cells in a canine disc degeneration model
Friday, August 17th, 2012
J Orthop Res. 2008 May;26(5):589-600 Authors: Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D Transplantation of mesenchymal stem cells (MSCs) is effective in decelerating disc degeneration in small animals; much remains unknown about this new therapy in larger animals or humans. Fas-ligand (FasL), which is only found [...]
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J Orthop Res. 2008 May;26(5):589-600 Authors: Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D Transplantation of mesenchymal stem cells (MSCs) is effective in decelerating disc degeneration in small animals; much remains unknown about this new therapy in larger animals or humans. Fas-ligand (FasL), which is only found [...]
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Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future
Friday, August 17th, 2012
J Cell Mol Med. 2008 Dec;12(6A):2205-16 Authors: Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI, Helder MN New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising. All cell types used so far require in vitro expansion prior to clinical use, as [...]
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J Cell Mol Med. 2008 Dec;12(6A):2205-16 Authors: Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI, Helder MN New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising. All cell types used so far require in vitro expansion prior to clinical use, as [...]
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Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge
Friday, August 17th, 2012
Neurosurg Focus. 2008;24(3-4):E21 Authors: Jandial R, Aryan HE, Park J, Taylor WT, Snyder EY Regenerative medicine and stem cells hold great promise for intervertebral disc (IVD) disease. The therapeutic implications of utilizing stem cells to repair degenerated discs and treat back pain are highly anticipated by both the clinical and scientific communities. Although the avascular [...]
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Neurosurg Focus. 2008;24(3-4):E21 Authors: Jandial R, Aryan HE, Park J, Taylor WT, Snyder EY Regenerative medicine and stem cells hold great promise for intervertebral disc (IVD) disease. The therapeutic implications of utilizing stem cells to repair degenerated discs and treat back pain are highly anticipated by both the clinical and scientific communities. Although the avascular [...]
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Coculture of bone marrow mesenchymal stem cells and nucleus pulposus cells modulate gene expression profile without cell fusion
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2008 Apr 15;33(8):870-6 Authors: Vadalà G, Studer RK, Sowa G, Spiezia F, Iucu C, Denaro V, Gilbertson LG, Kang JD STUDY DESIGN: Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. OBJECTIVE: To investigate the mechanisms of the [...]
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Spine (Phila Pa 1976). 2008 Apr 15;33(8):870-6 Authors: Vadalà G, Studer RK, Sowa G, Spiezia F, Iucu C, Denaro V, Gilbertson LG, Kang JD STUDY DESIGN: Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. OBJECTIVE: To investigate the mechanisms of the [...]
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Stem cell regeneration of degenerated intervertebral discs: current status.
Friday, August 17th, 2012
Curr Pain Headache Rep. 2008 Apr;12(2):83-8 Authors: Richardson SM, Hoyland JA Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there [...]
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Curr Pain Headache Rep. 2008 Apr;12(2):83-8 Authors: Richardson SM, Hoyland JA Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there [...]
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Disc regeneration: a glimpse of the future
Friday, August 17th, 2012
Clin Neurosurg. 2007;54:122-8 Authors: Tow BP, Hsu WK, Wang JC The normal IVD clinically acts to support and dissipate loads while permitting multiaxial motions of the spine. Its demanding mechanical function is provided by a well-defined microstructural organization and biochemical composition. IVD degeneration is a complex process that disrupts this well-defined organization and biochemical balance. [...]
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Clin Neurosurg. 2007;54:122-8 Authors: Tow BP, Hsu WK, Wang JC The normal IVD clinically acts to support and dissipate loads while permitting multiaxial motions of the spine. Its demanding mechanical function is provided by a well-defined microstructural organization and biochemical composition. IVD degeneration is a complex process that disrupts this well-defined organization and biochemical balance. [...]
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Magnetic resonance imaging of iron oxide labelled stem cells: applications to tissue engineering based regeneration of the intervertebral disc
Friday, August 17th, 2012
Eur Cell Mater. 2008;16:17-25 Authors: Saldanha KJ, Piper SL, Ainslie KM, Kim HT, Majumdar S Minimally-invasive monitoring of regeneration in diseased tissue is an important aspect of stem cell therapy. Magnetic resonance imaging (MRI) based tracking of cells labelled with ferumoxides has the potential for non-invasive in vivo detection and longitudinal assessment of implanted cells. [...]
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Eur Cell Mater. 2008;16:17-25 Authors: Saldanha KJ, Piper SL, Ainslie KM, Kim HT, Majumdar S Minimally-invasive monitoring of regeneration in diseased tissue is an important aspect of stem cell therapy. Magnetic resonance imaging (MRI) based tracking of cells labelled with ferumoxides has the potential for non-invasive in vivo detection and longitudinal assessment of implanted cells. [...]
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Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix
Friday, August 17th, 2012
Arthritis Res Ther. 2008;10(4):R89 Authors: Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN, Gruber HE INTRODUCTION: Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem cells (AD-MSC) from the sand rat to produce a proteoglycan and collagen type [...]
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Arthritis Res Ther. 2008;10(4):R89 Authors: Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN, Gruber HE INTRODUCTION: Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem cells (AD-MSC) from the sand rat to produce a proteoglycan and collagen type [...]
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Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation
Friday, August 17th, 2012
Am J Phys Med Rehabil. 2008 Sep;87(9):694-702 Authors: Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of [...]
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Am J Phys Med Rehabil. 2008 Sep;87(9):694-702 Authors: Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of [...]
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Clinical study of lumbar fusion by hybrid construct of stem cells technique and biodegradable material
Friday, August 17th, 2012
Zhonghua Wai Ke Za Zhi. 2008 Apr 1;46(7):493-6 Authors: Zhang P, Gan YK, Tang J, Hao YQ, Wang Y, Sun YH, Zhu ZA, Dai KR OBJECTIVE: To explorer the effectiveness of enriched bone marrow stem cells technique for lumbar fusion. METHODS: With the randomization and control principles, 2 graft materials [Enrichment bone marrow mesenchymal stem [...]
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Zhonghua Wai Ke Za Zhi. 2008 Apr 1;46(7):493-6 Authors: Zhang P, Gan YK, Tang J, Hao YQ, Wang Y, Sun YH, Zhu ZA, Dai KR OBJECTIVE: To explorer the effectiveness of enriched bone marrow stem cells technique for lumbar fusion. METHODS: With the randomization and control principles, 2 graft materials [Enrichment bone marrow mesenchymal stem [...]
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The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs
Friday, August 17th, 2012
J Orthop Res. 2009 Mar;27(3):374-9 Authors: Wei A, Tao H, Chung SA, Brisby H, Ma DD, Diwan AD Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study were to assess [...]
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J Orthop Res. 2009 Mar;27(3):374-9 Authors: Wei A, Tao H, Chung SA, Brisby H, Ma DD, Diwan AD Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study were to assess [...]
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Stem cell applications in intervertebral disc repair
Friday, August 17th, 2012
Cell Mol Biol (Noisy-le-grand). 2008;54(1):24-32 Authors: Hiyama A, Mochida J, Sakai D There is increasing rise of interest in stem cell therapy, as it provides new options for treating a broad range of diseases. Several experimental methods are being explored for the use of stem cells in delaying or reversing the degenerative process of the [...]
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Cell Mol Biol (Noisy-le-grand). 2008;54(1):24-32 Authors: Hiyama A, Mochida J, Sakai D There is increasing rise of interest in stem cell therapy, as it provides new options for treating a broad range of diseases. Several experimental methods are being explored for the use of stem cells in delaying or reversing the degenerative process of the [...]
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Tissue engineering and the intervertebral disc: the challenges
Friday, August 17th, 2012
Eur Spine J. 2008 Dec;17 Suppl 4:480-91 Authors: Kandel R, Roberts S, Urban JP Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers’ compensation benefits is significant. Surgical intervention as practised [...]
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Eur Spine J. 2008 Dec;17 Suppl 4:480-91 Authors: Kandel R, Roberts S, Urban JP Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers’ compensation benefits is significant. Surgical intervention as practised [...]
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Future perspectives of cell-based therapy for intervertebral disc disease
Friday, August 17th, 2012
Eur Spine J. 2008 Dec;17 Suppl 4:452-8 Authors: Sakai D. Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the spinal [...]
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Eur Spine J. 2008 Dec;17 Suppl 4:452-8 Authors: Sakai D. Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the spinal [...]
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Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 Authors: Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H STUDY DESIGN: Experimental and descriptive study of a xenotransplantation model in minipigs. OBJECTIVE: To study survival and function of human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as a [...]
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Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 Authors: Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H STUDY DESIGN: Experimental and descriptive study of a xenotransplantation model in minipigs. OBJECTIVE: To study survival and function of human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as a [...]
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MSC response to pH levels found in degenerating intervertebral discs
Friday, August 17th, 2012
Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9 Authors: Wuertz K, Godburn K, Iatridis JC Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats [...]
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Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9 Authors: Wuertz K, Godburn K, Iatridis JC Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats [...]
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An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue
Friday, August 17th, 2012
Arthritis Res Ther. 2009;11(1):R20 Authors: Le Maitre CL, Baird P, Freemont AJ, Hoyland JA INTRODUCTION: The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for [...]
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Arthritis Res Ther. 2009;11(1):R20 Authors: Le Maitre CL, Baird P, Freemont AJ, Hoyland JA INTRODUCTION: The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for [...]
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Expression and role of connective tissue growth factor in painful disc fibrosis and degeneration
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2009 Mar 1;34(5):E178-82 Authors: Peng B, Chen J, Kuang Z, Li D, Pang X, Zhang X STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions. OBJECTIVE: To study the expression and [...]
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Spine (Phila Pa 1976). 2009 Mar 1;34(5):E178-82 Authors: Peng B, Chen J, Kuang Z, Li D, Pang X, Zhang X STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions. OBJECTIVE: To study the expression and [...]
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In vivo intervertebral disc regeneration using stem cell-derived chondroprogenitors
Friday, August 17th, 2012
J Neurosurg Spine. 2009 Mar;10(3):265-72 Authors: Sheikh H, Zakharian K, De La Torre RP, Facek C, Vasquez A, Chaudhry GR, Svinarich D, Perez-Cruet MJ OBJECT: There is currently no biologic therapy to repair or restore a degenerated intervertebral disc. A potential solution may rest with embryonic stem cells (ESCs), which have a potential to grow [...]
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J Neurosurg Spine. 2009 Mar;10(3):265-72 Authors: Sheikh H, Zakharian K, De La Torre RP, Facek C, Vasquez A, Chaudhry GR, Svinarich D, Perez-Cruet MJ OBJECT: There is currently no biologic therapy to repair or restore a degenerated intervertebral disc. A potential solution may rest with embryonic stem cells (ESCs), which have a potential to grow [...]
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Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model
Friday, August 17th, 2012
Spine J. 2009 Jul;9(7):585-94 Authors: Murrell W, Sanford E, Anderberg L, Cavanagh B, Mackay-Sim A BACKGROUND: In humans, lower back pain is one of the most common causes of morbidity. Many studies implicate degeneration of intervertebral discs as the cause. In the normal intervertebral disc, the nucleus pulposus exerts a hydrostatic pressure against the constraining [...]
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Spine J. 2009 Jul;9(7):585-94 Authors: Murrell W, Sanford E, Anderberg L, Cavanagh B, Mackay-Sim A BACKGROUND: In humans, lower back pain is one of the most common causes of morbidity. Many studies implicate degeneration of intervertebral discs as the cause. In the normal intervertebral disc, the nucleus pulposus exerts a hydrostatic pressure against the constraining [...]
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Human disk cells from degenerated disks and mesenchymal stem cells in co-culture result in increased matrix production
Friday, August 17th, 2012
Cells Tissues Organs. 2010;191(1):2-11 Authors: Svanvik T, Henriksson HB, Karlsson C, Hagman M, Lindahl A, Brisby H Transplantation of mesenchymal stem cells (MSCs) has been suggested for disk degeneration, which is characterized by dysfunctional cells and low proteoglycan production. The aim of this study was to examine the effects of a 3D co-culture system using [...]
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Cells Tissues Organs. 2010;191(1):2-11 Authors: Svanvik T, Henriksson HB, Karlsson C, Hagman M, Lindahl A, Brisby H Transplantation of mesenchymal stem cells (MSCs) has been suggested for disk degeneration, which is characterized by dysfunctional cells and low proteoglycan production. The aim of this study was to examine the effects of a 3D co-culture system using [...]
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Biologic solutions for degenerative disk disease
Friday, August 17th, 2012
J Spinal Disord Tech. 2009 Jun;22(4):297-308 Authors: Fassett DR, Kurd MF, Vaccaro AR STUDY DESIGN: Literature review. OBJECTIVE: Review the potential use of biologic therapies for the treatment of degenerative disk disease. SUMMARY OF BACKGROUND DATA: Degeneration of the intervertebral disk is a common occurrence which, although asymptomatic in most instances, may result in axial [...]
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J Spinal Disord Tech. 2009 Jun;22(4):297-308 Authors: Fassett DR, Kurd MF, Vaccaro AR STUDY DESIGN: Literature review. OBJECTIVE: Review the potential use of biologic therapies for the treatment of degenerative disk disease. SUMMARY OF BACKGROUND DATA: Degeneration of the intervertebral disk is a common occurrence which, although asymptomatic in most instances, may result in axial [...]
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Cell-based regeneration of intervertebral disc defects: review and concepts
Friday, August 17th, 2012
Int J Artif Organs. 2009 Apr;32(4):197-203 Authors: Freimark D, Czermak P During the last century low back pain has emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD is a complex problem in which a variety of causes play a role. As IDD causes high costs, corporate interest has led to [...]
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Int J Artif Organs. 2009 Apr;32(4):197-203 Authors: Freimark D, Czermak P During the last century low back pain has emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD is a complex problem in which a variety of causes play a role. As IDD causes high costs, corporate interest has led to [...]
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Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells
Friday, August 17th, 2012
Mol Ther. 2009 Nov;17(11):1959-66 Authors: Yang F, Leung VY, Luk KD, Chan D, Cheung KM Degenerative disc disease (DDD) is a common disease which affects millions of people. Autograft of the bone marrow derived mesenchymal stem cells (BMSCs) have been shown to have the ability to arrest degeneration in rabbit and canine intervertebral discs. In [...]
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Mol Ther. 2009 Nov;17(11):1959-66 Authors: Yang F, Leung VY, Luk KD, Chan D, Cheung KM Degenerative disc disease (DDD) is a common disease which affects millions of people. Autograft of the bone marrow derived mesenchymal stem cells (BMSCs) have been shown to have the ability to arrest degeneration in rabbit and canine intervertebral discs. In [...]
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Nucleus pulposus tissue engineering: a brief review
Friday, August 17th, 2012
Eur Spine J. 2009 Nov;18(11):1564-72 Authors: Yang X, Li X Symptomatic intervertebral disc degeneration is associated with several spinal diseases, which cause losses of life quality and money. Tissue engineering provides a promising approach to recover the functionality of the degenerative intervertebral disc. Most studies are directed toward nucleus pulposus (NP) tissue engineering because disc [...]
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Eur Spine J. 2009 Nov;18(11):1564-72 Authors: Yang X, Li X Symptomatic intervertebral disc degeneration is associated with several spinal diseases, which cause losses of life quality and money. Tissue engineering provides a promising approach to recover the functionality of the degenerative intervertebral disc. Most studies are directed toward nucleus pulposus (NP) tissue engineering because disc [...]
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Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma
Friday, August 17th, 2012
Biomaterials. 2009 Oct;30(29):5523-33 Authors: Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP An ex vivo degenerative intervertebral disc (IVD) organ culture system was established for the screening of disc regeneration agents. Its application was demonstrated by a stem cell and growth [...]
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Biomaterials. 2009 Oct;30(29):5523-33 Authors: Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP An ex vivo degenerative intervertebral disc (IVD) organ culture system was established for the screening of disc regeneration agents. Its application was demonstrated by a stem cell and growth [...]
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Advances of nucleus pulposus cells for treating intervertebral disc degeneration
Friday, August 17th, 2012
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul;23(7):864-7 Authors: Wang F, Wang Y, Wu X OBJECTIVE: To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration. METHODS: The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive [...]
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul;23(7):864-7 Authors: Wang F, Wang Y, Wu X OBJECTIVE: To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration. METHODS: The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive [...]
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New perspectives on degenerative disease treatment
Friday, August 17th, 2012
Acta Reumatol Port. 2009 Apr-Jun;34(2B):327-35 Authors: da Silva MR, Domingues CJ, Pinto RP, Neves N, Matos RM, Tulha JM, Cabral AT The degenerative disc disease (DDD) is a chronic and multifactorial condition of the intervertebral disc that can manifest itself by axial pain, radiculopathy, myelopathy and spinal stenosis. It constitutes an increasing cause of lumbar [...]
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Acta Reumatol Port. 2009 Apr-Jun;34(2B):327-35 Authors: da Silva MR, Domingues CJ, Pinto RP, Neves N, Matos RM, Tulha JM, Cabral AT The degenerative disc disease (DDD) is a chronic and multifactorial condition of the intervertebral disc that can manifest itself by axial pain, radiculopathy, myelopathy and spinal stenosis. It constitutes an increasing cause of lumbar [...]
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Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2009 Oct 1;34(21):2297-304 Authors: Ganey T, Hutton WC, Moseley T, Hedrick M, Meisel HJ STUDY DESIGN: Therapeutic treatment of intervertebral disc repair using cells. OBJECTIVE: The goal of the study was to test the hypothesis that repair of a damaged disc is possible using autologous adipose tissue derived stem and regenerative [...]
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Spine (Phila Pa 1976). 2009 Oct 1;34(21):2297-304 Authors: Ganey T, Hutton WC, Moseley T, Hedrick M, Meisel HJ STUDY DESIGN: Therapeutic treatment of intervertebral disc repair using cells. OBJECTIVE: The goal of the study was to test the hypothesis that repair of a damaged disc is possible using autologous adipose tissue derived stem and regenerative [...]
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Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells
Friday, August 17th, 2012
J Orthop Res. 2010 May;28(5):623-30 Authors: Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J Activated nucleus pulposus (NP) cells can be reinserted into the disc to inhibit intervertebral disc degeneration. Experimental studies in animals showed that using a coculture system with direct cell-to-cell contact with mesenchymal stem cells (MSCs) [...]
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J Orthop Res. 2010 May;28(5):623-30 Authors: Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J Activated nucleus pulposus (NP) cells can be reinserted into the disc to inhibit intervertebral disc degeneration. Experimental studies in animals showed that using a coculture system with direct cell-to-cell contact with mesenchymal stem cells (MSCs) [...]
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Study on survival time of autogeneic BMSCs labeled with superparamagnetic iron oxide in rabbit intervertebral discs
Friday, August 17th, 2012
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Nov;23(11):1355-9 Authors: Tan S, Jia C, Liu Z, Liu R, Yang J, Zhang L, Shou F, Ju X OBJECTIVE: To explore the survival time of autogeneic BMSCs labeled by superparamagnetic iron oxide (SPIO) in rabbit intervertebral discs and the rule of migration so as to [...]
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Nov;23(11):1355-9 Authors: Tan S, Jia C, Liu Z, Liu R, Yang J, Zhang L, Shou F, Ju X OBJECTIVE: To explore the survival time of autogeneic BMSCs labeled by superparamagnetic iron oxide (SPIO) in rabbit intervertebral discs and the rule of migration so as to [...]
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Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs.
Friday, August 17th, 2012
Eur Spine J. 2010 Apr;19(4):601-12 Authors: Omlor GW, Bertram H, Kleinschmidt K, Fischer J, Brohm K, Guehring T, Anton M, Richter W Intervertebral disc (IVD) degeneration involves a series of biochemical and morphological changes leading to loss of spinal stability and flexibility. Cell therapy is promising to reconstitute IVDs with new cells, however, sustained metabolic [...]
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Eur Spine J. 2010 Apr;19(4):601-12 Authors: Omlor GW, Bertram H, Kleinschmidt K, Fischer J, Brohm K, Guehring T, Anton M, Richter W Intervertebral disc (IVD) degeneration involves a series of biochemical and morphological changes leading to loss of spinal stability and flexibility. Cell therapy is promising to reconstitute IVDs with new cells, however, sustained metabolic [...]
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Bone morphogenetic proteins in soft-tissue reconstruction
Friday, August 17th, 2012
Injury. 2009 Dec;40 Suppl 3:S17-20 Authors: Obert L, Lepage D, Gindraux F, Garbuio P Different options are reviewed in the field of musculoskeletal tissue reconstruction, from the addition of biological actors (cells, growth factors, biological or artificial scaffolds) to the application of gene therapy or tissue engineering. Growth factors can enable innovative solutions to treat [...]
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Injury. 2009 Dec;40 Suppl 3:S17-20 Authors: Obert L, Lepage D, Gindraux F, Garbuio P Different options are reviewed in the field of musculoskeletal tissue reconstruction, from the addition of biological actors (cells, growth factors, biological or artificial scaffolds) to the application of gene therapy or tissue engineering. Growth factors can enable innovative solutions to treat [...]
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Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies
Friday, August 17th, 2012
Spine (Phila Pa 1976). 2010 May 15;35(11):E475-80 Authors: Yoshikawa T, Ueda Y, Miyazaki K, Koizumi M, Takakura Y STUDY DESIGN: Marrow mesenchymal cells (MSCs) contain stem cells and possess the ability to regenerate bone, cartilage, and fibrous tissues. Here, we applied this regenerative ability to intervertebral disc regeneration therapy in an attempt to develop a [...]
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Spine (Phila Pa 1976). 2010 May 15;35(11):E475-80 Authors: Yoshikawa T, Ueda Y, Miyazaki K, Koizumi M, Takakura Y STUDY DESIGN: Marrow mesenchymal cells (MSCs) contain stem cells and possess the ability to regenerate bone, cartilage, and fibrous tissues. Here, we applied this regenerative ability to intervertebral disc regeneration therapy in an attempt to develop a [...]
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Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc
Friday, August 17th, 2012
J Bone Joint Surg Br. 2010 May;92(5):726-36 Authors: Hee HT, Ismail HD, Lim CT, Goh JC, Wong HK Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been [...]
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J Bone Joint Surg Br. 2010 May;92(5):726-36 Authors: Hee HT, Ismail HD, Lim CT, Goh JC, Wong HK Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been [...]
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Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC)
Friday, August 17th, 2012
Int J Artif Organs. 2010 Apr;33(4):244-52 Authors: Ehlicke F, Freimark D, Heil B, Dorresteijn A, Czermak P INTRODUCTION: One common cause of disability in modern society is low back pain. The main reason for this pain is the degeneration of the intervertebral disc (IVD), particularly of the nucleus pulposus (NP). For the early degeneration stage, [...]
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Int J Artif Organs. 2010 Apr;33(4):244-52 Authors: Ehlicke F, Freimark D, Heil B, Dorresteijn A, Czermak P INTRODUCTION: One common cause of disability in modern society is low back pain. The main reason for this pain is the degeneration of the intervertebral disc (IVD), particularly of the nucleus pulposus (NP). For the early degeneration stage, [...]
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Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model
Friday, August 17th, 2012
J Orthop Res. 2010 Oct;28(10):1267-1275 Authors: Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J Transplantation of mesenchymal stem cells (MSCs) inhibits the progression of disc degeneration in animal models. We know of no study to determine the optimal number of cells to transplant into the degenerated intervertebral disc (IVD). To determine [...]
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J Orthop Res. 2010 Oct;28(10):1267-1275 Authors: Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J Transplantation of mesenchymal stem cells (MSCs) inhibits the progression of disc degeneration in animal models. We know of no study to determine the optimal number of cells to transplant into the degenerated intervertebral disc (IVD). To determine [...]
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Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series
Friday, August 17th, 2012
Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical [...]
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Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical [...]
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